Experimental Murine Trypanosoma congolense Infections. I. Administration of Anti-IFN-g Antibodies Alters Trypanosome-Susceptible Mice to a Resistant-Like Phenotype

Experimental murine Trypanosoma congolense infections. I. Administration of anti-IFN-gamma antibodies alters trypanosome-susceptible mice to a resistant-like phenotype.

The mechanisms regulating resistance or susceptibility to African trypanosomes have been enigmatic. In this study, we assessed the production of several cytokines (IL-4, IFN-gamma, and TNF-alpha) in vivo and in vitro using genetically susceptible (BALB/c) or resistant (C57BL/6) mice infected with cloned Trypanosoma congolense and the role of these cytokines in pathogenesis of this infection. Pl...

Interleukin-17-mediated control of parasitemia in experimental Trypanosoma congolense infection in mice.

BALB/c mice are highly susceptible to experimental Trypanosoma congolense infections, whereas C57BL/6 mice are relatively resistant. Infected highly susceptible BALB/c mice die of systemic inflammatory response syndrome. Because interleukin-17 (IL-17) and Th17 cells regulate inflammatory responses, we investigated their role in the pathogenesis of experimental African trypanosomiasis in mice. W...

Molecular Regulation of Trypanosoma congolense-Induced Nitric Oxide Production in Macrophages

BALB/c mice are highly susceptible while C57BL/6 mice are relatively resistant to experimental Trypanosoma congolense infection. Several reports show that an early interferon-gamma (IFN-γ) response in infected mice is critically important for resistance via the activation of macrophages and production of nitric oxide (NO). NO is a pivotal effector molecule and possesses both cytostatic and cyto...

Experimental Murine Trypanosoma congolense Infections. II. Role of Splenic Adherent CD3 Thy1.2 TCR-ab gd CD48 and CD3 Thy1.2 TCR-ab gd CD48 Cells in the Production of IL-4, IL-10, and IFN-g and in Trypanosome-Elicited Immunosuppression

Alternative versus classical macrophage activation during experimental African trypanosomosis.

African trypanosomes are extracellular parasites causing sleeping sickness to human or nagana to livestock in sub-Saharan Africa. To gain insight into factors governing resistance/susceptibility to these parasites, the immune responses in mice infected with a Trypanosoma brucei phospholipase C null mutant (PLC(-/-)) or its wild type counterpart (WT) were compared. We found that the T. b. brucei...